Definition of rofecoxib
1.
(Chem. & Med.)
A
chemical
substance
(
C17H14O4S
,
molecular
weight
314
.
36
)
used
in
medicine
as
an
analgesic
to
alleviate
pain
and
inflammation
;
it
is
a
synthetic
compound
,
and
is
marketed
by
Merck
&
Co
.
under
the
trade
name
Vioxx
,
in
tablets
giving
dosages
of
12
.
5
or
25
milligrams
.
It
is
classed
as
a
non-steroidal
anti-inflammatory
drug
(
NSAID
).
Chemically
,
it
is
4-
[
4-
(
methylsulfony
)
phenyl
]-3-phenyl-2(
5H
)
furanone
.
Its
chemical structure
contains
two
phenyl
rings
and
a
furanone
ring
.
It
is
believed
to
act
by
inhibition
of
prostaglandin
biosynthesis
,
through
inhibition
of
the
enzyme
cyclooxygenase-2
(
COX-2
);
unlike
aspirin
,
it
does
not
inhibit
cyclooxygenase-1
.
Related Words
brand
,
brand
name
,
Cox-2
inhibitor
,
marque
,
trade
name
,
Vioxx
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