Penicillinase
Definition of Penicillinase
Pen`i`cil´lin`ase
n.
1.
(Bioch.)
An
enzyme
which
destroys
the
antibacterial
activity
of
penicillin
by
hydrolyzing
the
amide
bond
in
the
beta-lactam
ring
.
Many
penicillinases
are
known
,
and
are
produced
by
a
wide
variety
of
bacteria
.
The
production
of
penicillinase
is
one
of
the
mechanisms
by
which
bacteria
may
become
resistant
to
penicillins
.
Penicillinase
production
in
various
bacterial
species
may
be
induced
,
i
.
e
.,
it
may
occur
only
when
stimulated
by
the
presence
of
penicillin
in
the
culture
medium
,
or
it
may
be
constitutive
,
i
.
e
.,
it
may
occur
whenever
the
cells
are
producing
protein
.
Molecular
weights
of
the
various
penicillinases
tend
to
cluster
near
50
,
000
.
Related Words
beta-lactamase
,
enzyme
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